Chinese editing tools

Researchers from China's Zhejiang University coated the Cas9 protein with a layer of biomimetic cell membrane where they anchored a small molecule "switch," according to the study.

They found that in mice, a chemical arm of the switch would be activated by stimuli in ulcerative colons, thus activating the Cas9 tool to tone down the expression of disease-causing proteins. The study, published in the journal Science Advances, reported a CRISPR-Cas9 prodrug nanosystem that can transport a gene-editing protein exclusively to inflammatory lesions in mice colons and then "switch on" the protein. One shortcoming of the popular therapeutic tool however is that it can be imprecise, causing unwanted editing at other DNA sites.

Researchers from China's Zhejiang University coated the Cas9 protein with a layer of biomimetic cell membrane where they anchored a small molecule "switch," according to the study.

They found that in mice, a chemical arm of the switch would be activated by stimuli in ulcerative colons, thus activating the Cas9 tool to tone down the expression of disease-causing proteins. Yellow River in Dongying welcomes swans. CPC urged to keep drawing on experience.

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Magic grass spreads prosperity and peace overseas. Thank you, our superheroes. Know about China's national police day. Researchers from China's Zhejiang University coated the Cas9 protein with a layer of biomimetic cell membrane where they anchored a small molecule "switch," according to the study.

They found that in mice, a chemical arm of the switch would be activated by stimuli in ulcerative colons, thus activating the Cas9 tool to tone down the expression of disease-causing proteins.

The study revealed that the delivery tool maintains Cas9's high gene-editing level in mice colons while noticeably reducing editing in the liver, lung and spleen.